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The average age of board members is nearly 76.Yet in other ways Theranos evokes a central theme in today’s tech industry: startups which promise to disrupt lucrative businesses and become valued on the basis of fantasies about their potential, rather than present reality. “In order to do that, a bunch of things all along an analytical chain need innovations, all the way from collecting the sample to transferring a small quantity of blood into a high-performance analyzer,” says Eugene Chan, president of the DNA Medicine Institute. Theranos might not have been unique—overpromises and underdeliveries are as inimical to Silicon Valley as PowerPoint decks on laptops—but real diagnostics companies are making headway. Many of them are growing quickly. That’s home tests like for glucose or pregnancy, tests you might take at a pharmacy or clinic, and tests administered in hospitals. Hmm. In 2015 Alere—now owned by Abbott—got a CLIA waiver for a test for influenza based on extracting genetic material from a nasopharyngeal swab (way, way up your nose). But for the whole story, dig deep into the books, articles, podcasts and TV episodes about her. So what Theranos promised, and what many, many companies are still chasing, is a greater number of blood tests on very small amounts of blood. “You can run the blood and get results in 10 minutes,” says Narendra Soman, director of R&D for point-of-care diagnostics at Abbott.

And once it’s in there, moving teeny tiny volumes of liquid—more prone to hinky concentrations of what you’re looking for and what you’re not—through teeny tiny channels or containers that surface tension wants to make all sticky, doing not just one but many kinds of analyses, ain’t easy.If your company is trying to work with microsamples, it’s probably taking them from fingertips—but, as one good Chan has been working on this since at least 2014, when his DNA Medicine Institute won a $2.5 million X Prize competition to build a In the last decade, a recent report from Kalorama shows, the number of applications for approvals of molecular-based tests to the US government and the Europeans has risen. Too high means you’re having a heart attack; low and it’s probably just gas. That’s what’s behind all the cartridges, containers, and cards lots of diagnostics companies use. Devices that can download results directly to an electronic medical record are more common, and tests that use analytes other than blood—saliva, urine, or even breath—are coming on line. Published papers and preliminary tests have validated the Maverick’s ability to test for a variety of signals, and the company is now evaluating its use in a handful of San Diego doctors’ offices. The WIRED conversation illuminates how technology is changing every aspect of our lives—from culture to business, science to design. There’s something familiar about this, you are thinking.To be clear, Genalyte is no Theranos. … Formed twelve years ago after Ms Holmes dropped out of Stanford University, the firm has not raised capital from the usual suspects in the tech or medical businesses. The Inventor: Out for Blood in Silicon Valley. But if the allegations prove to be true, at the very least Theranos’s valuation may never again reach the heights seen so far.In several respects, Theranos is highly unusual in the tech industry.
Well, as early as the start of the century there was Abbott, whose i-Stat device is now in a third of all US hospitals. It was a $19.6 billion market in 2017, headed to $24.5 billion in 2022.Theranos’ implosion revealed more obstacles, though. It’s a handheld unit the size of a universal remote control; put a couple drops of blood onto a SD-card-like cartridge that fits into the unit and it’ll tell a physician or EMT whether someone with chest pain has, for example, elevated levels of a protein called troponin-I. The breakthroughs and innovations that we uncover lead to new ways of thinking, new connections, and new industries.Dozens of other companies were working on point-of-care blood testing before Theranos, and dozens still are.This Simple Paper Centrifuge Could Revolutionize Global HealthA Stanford researcher has created a groundbreaking scientific device using paper and string. Instead, Sheelah Kolhatkar writes, she changed the subject. Theranos said it was going to make $100 million in a year when it made about $100,000. The Theranos story fits almost too well into his formula, with reenactments bridging the gaps where the talking heads and the footage of Holmes gliding through the halls of an office complex stops. In early October, just before the bad headlines began, 31-year-old Ms Holmes, who is said to be the world’s youngest female self-made billionaire, was featured on the cover of Opinion can change as quickly as a pinprick. And that latter category, usually called CLIA, hasn’t expanded to include many of the newer tests, according to Kalorama.Those test technologies are changing quickly. But in terms of reaching profitability, they are often far behind the stockmarket-listed competitors they are seeking to displace, and thus are burning through cash. 5. Theranos, for example, is not believed to have any significant revenues or profits, yet it is valued about as highly as Quest Diagnostics, a listed laboratory company, which last year achieved $7.4 billion in revenues and nearly $600m in net profits.Many unicorns have been insulated from scrutiny, because they have no obligation to publish figures or provide progress reports on their technology. If they do not live up to their promise, their valuations will slump, either at their next funding round or when they finally go public. “But none of my analysts considered it to be a real company.”So what’s real?
There’s a difference among tests someone does to themselves at home, tests that a non-specialist can conduct reliably, and tests that an expert (like a phlebotomist) has to run.

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